Phase-coherent lightwave communications with frequency combs

Fiber-optical networks are a crucial telecommunication infrastructure in society. Wavelength division multiplexing allows for transmitting parallel data streams over the fiber bandwidth, and coherent detection enables the use of sophisticated modulation formats and electronic compensation of signal impairments. In the future, optical frequency combs may replace multiple lasers used for the different wavelength channels. We demonstrate two novel signal processing schemes that take advantage of the broadband phase coherence of optical frequency combs. This approach allows for a more efficient estimation and compensation of optical phase noise in coherent communication systems, which can significantly simplify the signal processing or increase the transmission performance. With further advances in space division multiplexing and chip-scale frequency comb sources, these findings pave the way for compact energy-efficient optical transceivers.Comment: 17 pages, 9 figure

Modulation format dependence on transmission reach in phase-sensitively amplified fiber links

Optical Society of America under the terms of the OSA Open Access Publishing Agreement We quantify the maximum transmission reach for phase-insensitive amplifier (PIA) and phase-sensitive amplifier (PSA) links with different modulation formats and show that the maximum transmission reach increase (MTRI) when using PSAs compared to PIAs is enhanced for higher-order modulation formats. The higher-order modulation formats are more susceptible to smaller phase rotations from nonlinearities, and PSAs are efficient in mitigating these smaller phase distortions. Numerical simulations were performed for single- and multi-span PIA and PSA links with single and multiple wavelength channels. We obtain a significant enhancement in the MTRI with PSAs compared to PIAs when using higher-order modulation formats for both the single- and multi-channel systems in single- and multi-span links. We verify the enhancement with a single-span, single-channel system experiment. We also demonstrate, for the first time, a 64-QAM modulation format fiber transmission in phase-sensitively amplified link, with a 13.3-dB maximum allowable span loss increase compared to a phase-insensitively amplified link

Phase-sensitively amplified wavelength-division multiplexed optical transmission systems

The throughput and reach in fiber-optic communication links are limited by in-line optical amplifier noise and the Kerr nonlinearity in the optical transmission fiber. Phase-sensitive amplifiers (PSAs) are capable of amplifying signals without adding excess noise and mitigating the impairments caused by the Kerr nonlinearity. However, the effectiveness of Kerr nonlinearity mitigation depends on the dispersion pre-compensation in each span. This paper investigates dense wavelength-division multiplexed PSA-amplified links using joint processing with a less complex digital domain Volterra nonlinear equalizer at the receiver. Both numerically and with experiments, it is shown that this significantly reduces the impact of the dispersion pre-compensation in each span. Also, with simulations, a substantial improvement in transmission reach is demonstrated for PSA links

Comparison of uniform cross QAM and probabilistically shaped QAM formats under the impact of transmitter impairments

Considering the nonideal response of Mach-Zehnder modulators, uniform cross QAM constellations improve upon probabilistically shaped QAM by a factor of up to 4 in uncoded symbol error rate and also offer higher achievable information rates, at the same source entropy and optimal electrical signal powers

Cybersecurity and medical devices: A practical guide for cardiac electrophysiologists

Medical devices increasingly depend on software. While this expands the ability of devices to perform key therapeutic and diagnostic functions, reliance on software inevitably causes exposure to hazards of security vulnerabilities. This article uses a recent high‐profile case example to outline a proactive approach to security awareness that incorporates a scientific, risk‐based analysis of security concerns that supports ongoing discussions with patients about their medical devices.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138357/1/pace13102_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138357/2/pace13102.pd

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodeling. Recently microglial cells have been shown to be responsible for a portion of synaptic remodeling, but the remaining mechanisms remain mysterious. Here we report a new role for astrocytes in actively engulfing CNS synapses. This process helps to mediate synapse elimination, requires the Megf10 and Mertk phagocytic pathways, and is strongly dependent on neuronal activity. Developing mice deficient in both astrocyte pathways fail to normally refine their retinogeniculate connections and retain excess functional synapses. Lastly, we show that in the adult mouse brain, astrocytes continuously engulf both excitatory and inhibitory synapses. These studies reveal a novel role for astrocytes in mediating synapse elimination in the developing and adult brain, identify Megf10 and Mertk as critical players in the synapse remodeling underlying neural circuit refinement, and have important implications for understanding learning and memory as well as neurological disease processes

Phase-sensitive amplifier link with distributed Raman amplification

We demonstrate long-haul transmission using a hybrid amplifier approach combining distributed Raman amplification and lumped phase-sensitive amplification. Aside from the well-known resulting SNR improvement, distributed Raman amplification is included in an effort to improve the nonlinearity mitigation capability of the phase-sensitive amplifiers. When changing from phase-insensitive operation to phase-sensitive operation in a link employing distributed Raman amplification, the transmission reach at BER = 10−3is increased from 15 to 44 spans of length 81 km while simultaneously increasing the optimal launch power by 2 dB

A prospective cohort study assessing clinical referral management & workforce allocation within a UK regional medical genetics service

Abstract Ensuring patient access to genomic information in the face of increasing demand requires clinicians to develop innovative ways of working. This paper presents the first empirical prospective observational cohort study of UK multi-disciplinary genetic service delivery. It describes and explores collaborative working practices including the utilisation and role of clinical geneticists and non-medical genetic counsellors. Six hundred and fifty new patients referred to a regional genetics service were tracked through 850 clinical contacts until discharge. Referral decisions regarding allocation of lead health professional assigned to the case were monitored, including the use of initial clinical contact guidelines. Significant differences were found in the cases led by genetic counsellors and those led by clinical geneticists. Around a sixth, 16.8% (109/650) of referrals were dealt with by a letter back to the referrer or re-directed to another service provider and 14.8% (80/541) of the remaining patients chose not to schedule an appointment. Of the remaining 461 patients, genetic counsellors were allocated as lead health professional for 46.2% (213/461). A further 61 patients did not attend. Of those who did, 86% (345/400) were discharged after one or two appointments. Genetic counsellors contributed to 95% (784/825) of total patient contacts. They provided 93.7% (395/432) of initial contacts and 26.8% (106/395) of patients were discharged at that point. The information from this study informed a planned service re-design. More research is needed to assess the effectiveness and efficiency of different models of collaborative multi-disciplinary working within genetics services. Keywords (MeSH terms) Genetic Services, Genetic Counseling, Interdisciplinary Communication, Cohort Studies, Delivery of Healthcare, Referral and Consultation

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the World Health Organization Prioritized Pathogens, is an emerging phlebovirus with a high fatality . Owing to the lack of therapies and vaccines , there is a pressing need to understand SFTSV pathogenesis. SFSTV non-structural protein (NSs) has been shown to block type I interferon induction and facilitate disease progression . Here, we report that SFTSV-NSs targets the tumour progression locus 2 (TPL2)-A20-binding inhibitor of NF-κB activation 2 (ABIN2)-p105 complex to induce the expression of interleukin-10 (IL-10) for viral pathogenesis. Using a combination of reverse genetics, a TPL2 kinase inhibitor and Tpl2 mice showed that NSs interacted with ABIN2 and promoted TPL2 complex formation and signalling activity, resulting in the marked upregulation of Il10 expression. Whereas SFTSV infection of wild-type mice led to rapid weight loss and death, Tpl2 mice or Il10 mice survived an infection. Furthermore, SFTSV-NSs P A and SFTSV-NSs K R that lost the ability to induce TPL2 signalling and IL-10 production showed drastically reduced pathogenesis. Remarkably, the exogenous administration of recombinant IL-10 effectively rescued the attenuated pathogenic activity of SFTSV-NSs P A, resulting in a lethal infection. Our study demonstrates that SFTSV-NSs targets the TPL2 signalling pathway to induce immune-suppressive IL-10 cytokine production as a means to dampen the host defence and promote viral pathogenesis

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodeling. Recently microglial cells have been shown to be responsible for a portion of synaptic remodeling, but the remaining mechanisms remain mysterious. Here we report a new role for astrocytes in actively engulfing CNS synapses. This process helps to mediate synapse elimination, requires the Megf10 and Mertk phagocytic pathways, and is strongly dependent on neuronal activity. Developing mice deficient in both astrocyte pathways fail to normally refine their retinogeniculate connections and retain excess functional synapses. Lastly, we show that in the adult mouse brain, astrocytes continuously engulf both excitatory and inhibitory synapses. These studies reveal a novel role for astrocytes in mediating synapse elimination in the developing and adult brain, identify Megf10 and Mertk as critical players in the synapse remodeling underlying neural circuit refinement, and have important implications for understanding learning and memory as well as neurological disease processes